Although the hallmark of Alzheimer's disease (AD) has been long recognized to be a profound deficit in episodic memory, subtle semantic deficits are often observed in AD patients even in the early stages of the illness, suggesting an early deterioration of brain areas underpinning semantic cognition. In this work we used resting-state fMRI to investigate the functional integrity of the semantic control network in mild AD patients. We found disease-associated functional alterations in key regions subserving semantic processing.
How low-frequency BOLD fluctuations are modulated when the brain is engaged in processing external stimuli is still poorly described. In this work we studied the modulations associated with a working memory task in the default mode network.
Sir Peter Mansfield, Nobel Prize in 2003 for his achievements in MRI, has recently died. Read here an interview about his figure (italian language).
The BOLD fMRI signal is usually exploited to map the brain activity, thanks to the local processing of inputs in the brain. In this work we showed that, if a cortical region is forced in a highly homogeneous state because of a stereotyped stimulation, then an amount of information can be coded in the temporal oscillations of the signal
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