Daniele Mascali received a Master’s degree in Physics from the Sapienza University of Rome in 2012 with a thesis on the negative BOLD response. Afterward, he received a Ph.D in “Morphofunctional science and Biophysics” with a thesis focused on the characterization of brain networks by means of resting-state fMRI. His main interest is the study of the brain function both in physiological and pathological conditions, particularly during neurodegenerative processes. He is also interested in several different aspects of the fMRI technique, from optimization of data acquisition to development of processing and data analysis methods. Since 2016 he has worked for the Enrico Fermi center; recently, as an exchange staff member of the European RISE project, he has moved to the Center for Magnetic R¬esonance Research (CMRR) in Minneapolis. Here, he aims to integrate functional MRI data with novel relaxations measurements, which are promising early biomarkers for the detection of microstructural damage in several brain diseases.